A graphical user interface for TCC package (called TCC-GUI). Non-R users need only have a web browser connected to the internet as a minimum setting. It is implemented in R and encapsulated as Shiny app. It contains major functionalities in TCC, i.e., the DE pipelines and generation of simulation data with various conditions. It also contains a useful measure (called average silhouettes) that indicates the degrees of separation for compared groups, several visualization tools included (MA plot, volcano plot et.al) or not included (MDS, PCA et.al) in the original TCC package, and a report generation tool with R Markdown. By virtue of the Shiny-based GUI framework, users can obtain these results with only mouse navigation.